Ryan Mathews ran for 98 yards and a pair of touchdowns, as the Chargers held on for a 20-17 victory over the struggling Chiefs.
Kansas City, last year’s AFC West champ, had possession in San Diego territory with under two minutes remaining, but Eric Weddle intercepted Matt Cassel to seal the win for the Chargers (2-1).
Cassel threw for 176 yards and two touchdowns. With Pro Bowl running back Jamaal Charles out for the season, the Chiefs (0-3) turned to Thomas Jones, who gained just 31 yards on 14 carries. Dexter McCluster was more effective, gaining 45 yards on nine carries.
Philip Rivers completed 24-of-38 passes for 266 yards and a pair of interceptions for San Diego, which won the division from 2006-09 before Kansas City went 10-6 to grab the title last season.